31 May 2017
InhibOx has relaunched as Oxford Drug Design to reflect its transition to a biotechnology company focused on internal drug discovery. Our lead antibacterial programme has identified compounds with the potential to be developed into therapies for Gram-negative bacterial infections, including against strains resistant to multiple current antibacterial drug classes. In the European Union alone, drug-resistant bacteria are estimated to cause 25,000 deaths and cost more than $1.5 billion every year in healthcare expenses and productivity losses. Compound design is supported by a proprietary technology platform in cheminformatics, 3D molecular similarity and computer-aided drug design that has been built up over 10 years of research and development.
The potential of our programme has been validated by the award of a prestigious Innovate UK Biomedical Catalyst grant to accelerate programme progression.
1 April 2017
Oxford Drug Design has raised nearly $2m (£1.5m) of private investment to enable it to progress a novel antibacterial programme and continue to build its proprietary platform.
The funding, which will also help finance the company’s commercial and research and development (R&D) activities, was supported by both existing shareholders including IP Group plc as well as new investors including Busolantix Investment SA, O2h Ventures and a number of Business Angels.
Oxford Drug Design will continue to build and utilise its proprietary technology platform in cheminformatics, 3D molecular similarity and computer-aided drug design, in parallel with progressing the antibacterial programme.
1 March 2017
Oxford Drug Design (formerly InhibOx) has started work on a $1.1m (£900k) grant funded project to develop novel antibiotics. The project started four years ago as part of an EU-funded collaboration into multi-drug resistance. Capitalising on drug design, chemical synthesis and biology skills across the consortium, they have discovered new molecules with activity against a range of Gram-negative bacteria. The new money comes from Innovate UK, the UK's innovation agency, as part of the biomedical catalyst fund and will be used to design dual target inhibitors of aminoacyl tRNA synthetases for the treatment of multi-drug-resistant infections.
The compounds discovered so far inhibit a member of the tRNA synthetase family which plays a key role in protein biosynthesis. They have activity against a range of Gram-negative bacteria but need to be improved in terms of the level of activity and stability. This class of bacteria (which includes species such as E. coli and Klebsiella) has an extra layer to their cell wall. This provides them with an additional barrier to drug penetration, making them much harder to treat. By targeting more than one tRNA synthetase improvements should be seen in terms of both activity and decreased levels of bacterial resistance.
The next steps are to optimise the molecules to enhance their activity and stability and to monitor the emergence of resistance. The design work will be carried by over the next two years with the aim of developing a candidate ready for clinical testing.